iBEST Researchers

iBEST RESEARCHERS

Members of the Institute for Biomedical Engineering, Science and Technology (iBEST) are leaders in their fields who will not only pioneer new medical technologies, but also guide fundamental research “from bench to bedside.”

Dr. Andrew Baker

Dr. Andrew Baker

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Baker is a critical care physician with research foci on the physiology, clinical monitoring, and treatment of brain injury. Dr. Baker analyzes blast-induced brain injuries, including concussions, to look at new biologic therapy to reduce brain injury and improve functional outcomes.

Visit Dr. Baker’s website

Dr. Jennifer Beck

Dr. Jennifer Beck

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Beck studies how the brain controls breathing, diaphragm physiology, and non-invasive ventilation. She is currently focused on developing newer modes of mechanical ventilation and improving clinical outcomes in patients from all age groups. She is collaborating with various Intensive Care Units in Canada, the United States, and Europe.

Visit Dr. Beck’s website

Habiba Bougherara

Dr. Habiba Bougherara

Mechanical & Industrial Engineering
Ryerson University

Dr. Bougherara focuses on the interface between implants and bones. Her research team is among the first in Canada to explore the use of green material for medical implants, developing innovative synthetic implants that reduce the use of non-renewable resources.

Visit Dr. Bougherara’s website

Dr. Laurent Brochard

Dr. Laurent Brochard

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Brochard studies mechanical ventilation, acute respiratory failure, patient-ventilator interaction, and acute respiratory distress syndrome. Dr. Brochard’s developed several bench models for simulating patient-ventilator interaction and for assessing the performance of mechanical ventilators and related devices.

Visit Dr. Brochard’s website

Kim Connelly (B&W)

Dr. Kim Connelly

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Karen Cross bw

Dr. Karen Cross

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Dr. Timothy Daniels

Dr. Timothy Daniels

Li Ka Shing Knowledge Institute
St. Michael's Hospital

Dr. Daniels is a member of the Canadian Orthopaedic Foot and Ankle Society research team. His research interests include foot and ankle, ankle arthritis, ankle arthroplasty, gait mechanics, foot and ankle deformities, and first metatarsophalangeal arthritis.

Visit Dr. Daniels’s website

Alexandre Douplik

Dr. Alexandre Douplik

Physics
Ryerson University

Dr. Douplik’s research has resulted in innovative advances in the areas of laser surgery and related technologies such as fluorescence endoscopy and spectral imaging in cancer diagnostics and therapy. Biomedical applications of his work include nanoscale and metamaterial technologies, fuelling the next generation of precision medical diagnostic and therapeutic instruments.

Visit Dr. Douplik’s website

Greg Fairn

Dr. Greg Fairn

Keenan Research Centre for Biomedical Science
St. Michael’s Hospital

Dr. Fairn’s research interests include cellular signaling, innate immunity, lipid biochemistry, microbiology, and cellular imaging. His research lab is currently focused on the formation and role of membrane nanodomains and nanoparticles in cellular signaling and communication.

Visit Dr. Fairn’s website

Howard Ginsberg

Dr. Howard Ginsberg

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Ginsberg’s research focuses on engineering applications for neurosurgical procedures. His goal is improving safety and outcome for patients. His current projects include a novel strategy for image guidance in spinal surgery, surgical simulation for the purpose of teaching and pre-operative planning, as well as development of new surgical devices and approaches.

Visit Dr. Ginsberg’s website

Teodor Grantcharov

Dr. Teodor Grantcharov

Li Ka Shing Knowledge Institute
St. Michael’s Hospital

Dr. Grantcharov studies the development, assessment, and implementation of new training methods for surgeons. Dr. Grantcharov uses state-of-the-art, virtual-reality computer simulators to train for basic and advanced laparoscopic procedures. His surgical skills lab investigates the impact of evidence-based training curriculum on skills acquisition for minimally invasive surgery. These curricula have now been implemented by numerous academic healthcare institutions nationally and internationally and have made a profound difference in the way surgeons are trained and assessed.

Visit Dr. Grantcharov’s website

Greg Hare

Dr. Greg Hare

Keenan Research Centre for Biomedical Science
St. Michael’s Hospital

Dr. Hare’s research interests include mechanisms of organ injury associated with acute anemia, hypoxic cellular mechanisms, nitric oxide synthase, development of blood substitutes, and blood conservation. He has built strong collaborative relationships within multiple departments at the University of Toronto, and internationally at the University of Pennsylvania and Cornell University.

Visit Dr. Hare’s website

Dae Kun Hwang

Dr. Dae Kun Hwang

Chemical Engineering
Ryerson University

Dr. Hwang’s research includes micro/nanofabrication technologies, including labs-on-a-chip that operate on a nano scale and reduce the time for product synthesis and analysis. He is currently investigating the secrets of spider silk production, using the biological structure, function, and composition of the silks to create biodegradable material fibres stronger than man-made superfibres like Kevlar.

Visit Dr. Hwang’s website

Andras Kapus

Dr. Andras Kapus

Keenan Research Centre for Biomedical Science
St. Michael’s Hospital

Dr. Kapus aims to gain insight into basic cellular and molecular mechanisms underlying the process of organ scarring. Organ scarring, or fibrosis, is the common final pathway of many chronic diseases affecting the kidney, lung and liver. He is particularly interested in how changes in the cell structure (cytoskeleton) reprogram long-term cell functions (gene expression) and thereby alter tissue characteristics. He also studies how cells cope with stress conditions, particularly with dehydration and volume changes, that occur in a variety of disease states including diabetes, trauma, and heart failure.

Visit Dr. Kapus’s website

Raffi Karshafian

Dr. Raffi Karshafian

Physics
Ryerson University

Dr. Karshafian is developing new applications for ultrasound in combination with microbubbles for medical imaging and therapeutics. His research group is specifically interested in improving local drug delivery of medicinal drugs and in enhancing the sensitivity of tumours to ionizing radiation.

Visit Dr. Karshafian’s website

April

Dr. April Khademi

Electrical & Computer Engineering
Ryerson University

Dr. Khademi focuses on the design of algorithms that extract quantitative biomarkers from pathology and radiology images.  In pathology images, she primarily focuses on H&E and IHC scoring and grading systems for breast cancer disease.  In neurological MRI, she applies algorithms to study neurodegeneration (AD/MS/ischemic disease), as well as brain cancer metastasis. Of particular interest is whether imaging-based precursors can shed light into disease causation and progression, and can be used to predict a patient’s prognosis.   Algorithm commercialization is a major focus of Dr. Khademi’s lab.

Visit Dr. Khademi’s website

Michael Kolios

Dr. Michael Kolios

Physics
Ryerson University

Dr. Kolios is examining the potential of using high frequency ultrasound imaging (20-60MHz) for the detection of cell death. He is also investigating the use of acoustic cameras to monitor treated tissue non-invasively. He aims to bring new ultrasound innovations to global hospitals and clinics in collaboration with health care research institutes.

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Sri Krishnan

Dr. Sri Krishnan

Electrical & Computer Engineering
Ryerson University

Dr. Krishnan’s research program is exploring physiological health signals such as sound patterns, ECG, EMG, and EEG, discovering how to identify patterns using signal processing and machine learning algorithms. This research involves adaptive signal representation and analysis, biomedical signal/image analysis, wearables and information technology, compressive sensing, and data analytics.

Visit Dr. Krishnan’s website

Wolfgang Kuebler

Dr. Wolfgang Kuebler

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Kuebler studies lung vascular biology, acute lung injury, lung fluid balance, pulmonary hypertension and other chronic lung diseases. In his work, he integrates basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism and applies this knowledge for the development and pre-clinical testing of new therapeutic strategies for the treatment of these diseases.

Visit Dr. Kuebler’s website

John Laffey (B&W)

Dr. John Laffey

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Warren Lee

Dr. Warren Lee

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Lee’s work centres on understanding the cellular and molecular basis of microvascular endothelial barrier function, especially how the permeability of the microvasculature is regulated during infections or inflammatory conditions such as sepsis. Dr. Lee’s work uses a combination of live cell imaging, electron microscopy, and traditional biochemical and molecular biological approaches.

Visit Dr. Lee’s website

Howard Leong-Poi

Dr. Howard Leong-Poi

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Leong-Poi focuses on the development of new therapeutic applications for contrast ultrasound and carrier microbubbles, specifically novel gene therapies to treat acute myocardial infarction, heart failure, chronic peripheral arterial disease and cancers.

Visit Dr. Leong-Poi’s website

General Leung (B&W)

Dr. General Leung

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Tom Marotta

Dr. Tom Marotta

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Marotta’s research interests include aneurysm diagnosis and surgery, three-dimensional imaging, magnetic resonance angiography, x-ray computed tomography, and blood vessel prosthesis.

Visit Dr. Marotta’s website

Philip Marsden

Dr. Philip Marsden

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Marsden’s research program focuses on cellular and molecular regulation of endothelial gene expression. Specifically, his lab aims to understand the contribution of endothelial cells and genes to human health and disease.

Visit Dr. Marsden’s website

John Marshall

Dr. John Marshall

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Marshall researches sepsis, innate immunity, host-microbial interactions, and nosocomial infection. Dr. Marshall also has an active interest in clinical trials in the critically ill, including an international pilot study of the efficacy of statins in patients with severe H1N1 disease.

Visit Dr. Marshall’s website

Gaspard Motandon (B&W)

Dr. Gaspard Montandon

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Heyu Ni

Dr. Heyu Ni

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Ni conducts blood research in topics including thrombosis and hemostasis, platelet physiology, vascular biology, immune response to allo- and auto-antigens, adhesion molecules, and intra-vital microscopy.

Visit Dr. Ni’s website

Ori Rotstein

Dr. Ori Rotstein

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Trauma victims are at increased risk of developing organ injury shortly after trauma. Dr. Rotstein’s lab studies the cellular and molecular mechanisms predisposing trauma victims to developing organ dysfunction.

Visit Dr. Rotstein’s website

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Dr. Alireza Sadeghian

Computer Science
Ryerson University
Claudia Dos Santos (B&W)

Dr. Claudia dos Santos

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Tom Schweizer

Dr. Tom Schweizer

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Schweizer uses advanced imaging and other technology to identify what happens in the brain during illness—such as aneurysms, dementia and traumatic brain injury—or during everyday occurrences, such as driving with a cell phone.

Visit Dr. Schweizer’s website

Christer Sinderby

Dr. Christer Sinderby

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Sinderby’s research interests include mechanical ventilation, such as neural control of mechanical ventilation, patient-ventilator interaction, and respiratory muscle function. Dr. Sinderby’s work typically covers all steps from bench to bedside, including original publications, patent filing and knowledge translation educating industrial partners or end users.

Visit Dr. Sinderby’s website

Katalin Szaszi

Dr. Katalin Szaszi

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Szaszi’s current research explores the biology of epithelial cells. She studies the molecular mechanisms that control cell architecture and intercellular junctions in epithelial cells that make up kidney tubules and explores how inflammation induces functional alterations. Her work focuses on Rho family small GTPases, guanine nucleotide exchange factors that regulate these proteins, and on claudins, that are molecules found in the tight junctions mediating paracellular permeability.

Visit Dr. Szaszi’s website

Jahan Tavakkoli

Dr. Jahan Tavakkoli

Physics
Ryerson University

Dr. Tavakkoli’s work spans a range of novel therapeutic and diagnostic applications of ultrasound in medicine and biology including image-guided surgical techniques that can effectively be used in a number of minimally-invasive surgery procedures. His research on imaging technology investigates models and simulation tools that can significantly enhance our understanding of ultrasound bio-effects.

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Vladislav Toronov (B&W)

Dr. Vladislav Toronov

Physics
Ryerson University
Mark Towler

Dr. Mark Towler

Biomedical Engineering
Ryerson University

Dr. Towler’s research program is focused on the development and commercialization of medical devices for hard tissue applications and in-vitro diagnostics, which have musculoskeletal applications in both industry and academia. To date, this research has resulted in two spin-off companies: Crescent Diagnostics Limited and Bearna Medical.

Visit Dr. Towler’s website

Scott Tsai

Dr. Scott Tsai

Mechanical & Industrial Engineering
Ryerson University

Dr. Tsai’s research applies small-scale fluidic systems to coat microscopic particles, with the eventual goal of coating single cells with thin layers of polymers. This will result in the creation of small medical devices and smart biomedical materials to solve problems in biotechnology, producing innovations in the biomedicine and environmental sustainability sectors.

Visit Dr. Tsai’s website

Karthi Umapathy

Dr. Karthi Umapathy

Electrical & Computer Engineering
Ryerson University

Dr. Umapathy’s research interests include biomedical signal and image analysis, time-frequency analysis, digital signal processing, cardiac electrophysiology, and magnetic resonance imaging. One of his recent projects involves studying the electrical activity on the surface of the human heart during ventricular fibrillation to reduce sudden cardiac death in North America.

Visit Dr. Umapathy’s website

Karen Cross bw

Dr. Krishnan Venkatakrishnan

Mechanical and Industrial Engineering
Ryerson University
Subodh Verma bw

Subodh Verma

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Steve Waldman

Dr. Steve Waldman

Chemical Engineering
Ryerson University

Dr. Waldman’s research centres on developing techniques for growing cartilage to support patients needing prosthetic limbs, and extends to growing cartilage for the ears, nose, or throat. This research has significant potential to help victims of severe burns or accidents.

Visit Dr. Waldman’s website

Xiao-Yan Wen (B&W)

Dr. Xiao-Yan Wen

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Yeni Yucel

Dr. Yeni Yucel

Keenan Research Centre for Biomedical Science
St. Michael's Hospital

Dr. Yucel’s major research interests relate to retina and optic nerve as a model to study neurodegenerative diseases such as glaucoma, age-related macular degeneration, Alzheimer disease and amyotrophic lateral sclerosis. These research activities are integrated within a translational research program to improve the diagnosis and treatment of patients with various types of neural injury. Dr. Yucel’s group is investigating also the role of the lymphatics in drainage of fluid and proteins from the eye and brain, in health and disease.

Visit Dr. Yucel’s website

Darren Yeun (B&W)

Dr. Darren Yuen

Keenan Research Centre for Biomedical Science
St. Michael's Hospital
Haibo Zhang (B&W)

Dr. Haibo Zhang

Keenan Research Centre for Biomedical Science
St. Michael's Hospital